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QLEDs â light-emitting diodes that rely on nanocrystals called quantum dots â are usually made with toxic heavy metals. A strategy has been developed to make QLEDs with a performance comparable to that of commercially available technologies but using a more environmentally friendly alloy of zinc, selenium, telluriu
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Ketone signaling goes nuclear - Nature Chemical Biology
2+ day, 4+ hour ago (155+ words) Nature Chemical Biology (2026) Cite this article The nucleus is increasingly recognized as a metabolically active hub. A study shows how the ketolytic enzyme OXCT1 translocates to the nucleus to locally deplete β-hydroxybutyrate, suppressing anti-tumor immunity through site-specific epigenetic remodeling. van der…...
ATP-independent unfolding of ubiquitin by Ufd1 initiates Cdc48/p97-mediated substrate processing | Nature Structural & Molecular Biology
2+ day, 15+ hour ago (1569+ words) Nature Structural & Molecular Biology (2026) Cite this article Coordinates and structure files were deposited to the Protein Data Bank under accession code PDB 22ID (ctUT3–C19). Any additional information required to reanalyze the data reported in this paper is available upon request. Source data…...
HDAC1 maintains metabolic homeostasis in nucleus pulposus cells via post-translational modification interactions with YBX1 | Experimental & Molecular Medicine
3+ day, 13+ hour ago (1604+ words) Experimental & Molecular Medicine (2026) Cite this article The mechanical properties were comprehensively assessed using tensile tests. Cylindrical GelMA specimens (10 mm length, 10 mm diameter) crosslinked under 405 nm UV light were secured at one end and subjected to controlled pulling at the opposite…...
‘Superdark’ protein looks like a G-protein-coupled receptor — but shows unconventional behaviour
3+ day, 10+ hour ago (19+ words) Mining millions of AI-predicted structures reveals an evolutionarily conserved protein that resembles a receptor family member but functions differently....
The metabolic road from α-cells to β-cells - Nature Chemical Biology
3+ day, 14+ hour ago (70+ words) Nature Chemical Biology (2026) Cite this article Pancreatic α-cells can be redirected along a metabolic road toward an insulin-producing β-cell-like identity. A study reveals that an epigenetic–metabolic axis centered on PRC2 and androgen receptor signaling governs endocrine cell fate and charts…...
Macrophages transfer functional proteins to their surface during live-cell uptake | Nature Chemical Biology
4+ day, 15+ hour ago (1629+ words) Nature Chemical Biology (2026) Cite this article Here, we developed and applied chemical biology techniques to reveal that membrane proteins on target cells are transferred intact to the surface of macrophages. This process requires cell–cell contacts and is functionally important…...
Determining the dark proteome - Nature Chemical Biology
4+ day, 14+ hour ago (157+ words) Nature Chemical Biology (2026) Cite this article The human genome comprises both canonical protein-coding genes and a vast number of non-canonical coding regions, yet the translation products of the latter remain largely underexplored. Now, the TransCODE Consortium provides a systematic view…...
Macrophages are what they eat - Nature Chemical Biology
4+ day, 14+ hour ago (73+ words) Nature Chemical Biology (2026) Cite this article Macrophages that are reprogrammed by the tumor microenvironment drive cancer growth and immune evasion. Mass spectrometry now shows that proteins of cells eaten by macrophages can retain their function, and that cell surface proteins…...
Adjusting α-cell metabolism induces β-cell features - Nature Reviews Endocrinology
5+ day, 5+ hour ago (232+ words) Adjusting α-cell metabolism induces β-cell features Nature Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or…...
Neutrophils in cancer | Nature Reviews Cancer
5+ day, 7+ hour ago (650+ words) Nature Reviews Cancer (2026) Cite this article Wolach, O. et al. Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms. Sci. Transl. Med. 10, eaan8292 (2018). Wada, Y. et al. Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF…...